Methods Mice acetic acid writhing test, mice heat radiation tail flick assay and mice abstinent jumping test were used to analysis the sites of agmatine modulation on morphine analgesia and tolerance to and dependence on morphine by intracerebroventricular ( icv) and intrathecal ( itt) injection. 方法在小鼠醋酸扭体、热辐射甩尾、物质依赖戒断等模型上,采用脑室和脊髓给药的方法,分析胍丁胺对***药理作用的中枢部位。